ADJUVANTS ON THE BASIS OF SQUALES IN VACCINES: WHY IS IT IMPORTANT

Автор - | 04.02.2019

We constantly write about the benefits of amaranth. Including, mentioning that in amaranth oil in large quantities contains such an element as squalene. It turns out that back in 2006, the World Health Organization published an article on its website, which tells about the possibility (and importance) of using squalene-based adjuvants in vaccines.

That is, it suggests that amaranth is becoming a very important and valuable natural source of squalene used in the pharmaceutical industry. In particular, in the production of vaccines.

Note! Adjuvants – a compound or complex of substances used to enhance the immune response when administered simultaneously with the immunogen. Unlike immunomodulators, they are used to enhance a specific immune response (for example, during vaccination) most often in a healthy body, and not to normalize impaired reactions of the immune system in pathology.

What exactly focused WHO experts? Let’s talk about it.

What is squalene?
As WHO experts say in their report, squalene is a natural, natural component found in nature. In particular, it is found in animals, in plants, and even in humans. Squalene is produced in the human liver and then enters the blood and circulates in the circulatory system. Skvalen in vaccines

The presence of squalene was also detected in a number of foods. It is used in the manufacture of cosmetics, medicines, as well as dietary supplements.

Squalene is obtained from the liver of deep-sea sharks, some other species of fish. Initially, the substance, before it will be used in the manufacture of medicines, undergoes special purification. (Recall, this is a material published by WHO back in 2006).

Is squalene used in vaccine production?
Squalene was first used in vaccines in 1997 — the substance was contained in the FLUAD vaccine, manufactured by Chiron. Up to 10 milligrams of squalene accounted for one dose of vaccine – this rule was officially approved by specialized institutions. In this vaccine, the substance is present in the form of an emulsion, which increased the immunogenicity of the drug.

In addition, squalene was used to increase the overall level of effectiveness of some experimental vaccines — among them:

  • pandemic influenza vaccines;
  • vaccine against malaria.

What is the need to add squalene to vaccines
According to WHO experts, squalene is a component of several adjuvants added directly to vaccines, which provides an increase in the immune response.

In particular, in their conclusions, WHO experts note that a similar example of vaccines is MF59 – this type of adjuvant is produced by the manufacturer Novartis and added to the FLUAD vaccine used for vaccination against influenza

According to experts, squalene itself cannot be an adjuvant, however, the squalene emulsion in which surfactants are present significantly enhances the immune response.

Has squalene been safe in vaccines?
It is indicated that from 1997 to 2006, 22 million FLUAD vaccine from Chiron was used. All 22 million users were completely safe. Each dose was about 10 milligrams of squalene. No side effects have been identified. Only in some cases local reactogenicity was noted.

In addition, specialists in the field of vaccination conducted clinical studies of vaccines, which include squalene, among infants and newborns. There are no adverse reactions, effects or manifestations that can indicate the danger of squalene in vaccines.

Where does information come from that squalene can be dangerous?
It turns out that the information was spread – ostensibly squalene, which is present in vaccines, can lead to health problems. Some people have pointed out that the health problems experienced by war veterans in the Persian Gulf are probably related to squalene, which was added to vaccines.

In particular, data was published – there were statements that veterans who were injected with anthrax vaccine had developed antibodies to squalene, which provoked disability.

However, later it was found that in vaccines that were administered to veterans, in fact, there was no squalene. And in the published data errors were found.

Summarizing
As you can see, squalene is a very useful substance. As you know, it helps to prolong the body’s youth. However, as shown by studies published by the World Health Organization in 2006, squalene is also useful when creating vaccines.

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